In what ways can the psychedelic imagination be “transformative”? The science of psychedelics is having a renaissance currently and the research is helping us understand the mind better and provide us with fresh therapeutic options. Psychotropic substances engender psychological and philosophical states that reveal important features of the self and consciousness. They can reduce the vigilant executive functions in the frontal areas of the brain and release the mind into the involuntary sphere of free-association and mind-wandering (what neuroscientists call the Default Mode Network, DMN). These altered states loosen the tyranny of task-based consciousness, and they also suspend the ego’s usual dominance –letting us feel connected to everything (possibly activating improved empathy).